Holsom.

The evidence

The research behind our ingredients.

We built Holsom on ingredients that have been studied in published, peer-reviewed research. Below are references for each active in the formula. These are studies on the individual ingredients, not on the finished Holsom product, and they describe how these ingredients have been studied, not a promise of specific results. We believe in showing our work.

NAC (N-Acetyl Cysteine)

600 mg per daily serving

Why it's in Holsom: A precursor the body uses to make glutathione, the antioxidant the liver relies on.

  • Systematic review and meta-analysis of controlled clinical trials on NAC and liver function

    Clinical Nutrition ESPEN, 2023

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  • World Health Organization documentation of NAC as a glutathione precursor

    WHO Model List / EML application, 2021

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  • NAC and glutathione levels, randomized placebo-controlled trial

    Scientific Reports (Nature), 2021

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Milk Thistle (Silymarin)

265 mg per daily serving

Why it's in Holsom: Standardized for silymarin, the fraction studied for supporting liver cells.

  • The therapeutic effect of silymarin in nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials

    Medicine, 2017

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  • Impact of silymarin supplements on liver enzyme levels: a systematic review of RCTs (29 trials, 3,846 participants)

    Phytotherapy literature review, 2023

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  • Administration of silymarin in NAFLD/NASH: a systematic review and meta-analysis (26 RCTs)

    Systematic review, 2023

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Artichoke Leaf Extract

500 mg per daily serving

Why it's in Holsom: Studied for supporting healthy bile flow and everyday fat digestion.

  • Panahi Y, et al. Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: a pilot double-blind randomized controlled trial

    Phytotherapy Research, 2018

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Research on an ingredient describes how it has been studied. It is not a guarantee of individual results. Holsom supports your body's own liver function and is not intended to diagnose, treat, cure, or prevent any disease.